Please know that the sponsors of this site are not responsible for content on the site you are about to enter. WebYour doctor may prescribe calcium and vitamin D to help prevent low calcium levels in People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including endocarditis and serious infections of the skin, abdominal, urinary tract, and ear. To learn about other mild side effects, talk with your doctor or pharmacist, or read Prolias medication guide. With osteoporosis, your bones become porous, meaning there are large holes within your bone tissue. You might be interested in seeing how Prolia and the drug Boniva compare. You might wonder how Prolia and the drug Xgeva compare. Others may continue for as long as you take the drug, but they can be easily managed. Xgeva is also used to treat giant cell tumor of the bone. Every 6 months youll get another dose of Prolia. But if you look at D3 supplements online, youll see that most commercial supplements have higher doses usually either 1,000, 2,000, 5,000 or 10,000 IU. Learn about compression fractures, preventive medications, and, Preventing osteoporosis can help you prevent fractures and maintain strength as you age. Mild side effects can occur with Prolia use. The drug attaches to the RANK protein and helps prevent osteoclasts from breaking down bone. To learn more about this side effect, see Side effect specifics below. Do not use denosumab if you are pregnant. Prolia Side Effects: Common, Mild, and Serious - Healthline If your pain doesnt ease with OTC options, your doctor may suggest prescription pain medication. WebIn many individuals, calcium supplements are better absorbed when taken with food. Prolia - Patient Information Leaflet (PIL) - (emc) - medicines Denosumab (Prolia) for postmenopausal osteoporosis Its recommended that calcium and vitamin D supplements be taken with Prolia. Keep out of the reach of children and pets. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. Q: Does AlgaePlus Increase Bone Mass? Instead, it belongs to a different group of medications called biologics. If you miss a dose of Prolia, you should receive your injection as soon as you can. They also include any added costs of the drug being given by a healthcare professional. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines It may not cover all possible information. If youre breastfeeding, you should not receive Prolia. Bring someone with you to your appointment if doing so will help you feel more comfortable. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. You should talk with your doctor if you develop any mild side effects that concern you. You can learn more about how we ensure our content is accurate and current by reading our. Web You will receive Prolia 1 time every 6 months. Osteoporosis treatment: Medications can help - Mayo Clinic What Health Changes Should You Expect Postmenopause? Specifically, its used to increase bone mass in: Osteopenia (low bone mass), and low bone mineral density (BMD) can occur with older age. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. They have some similar uses and side effects, but they also have some differences. Prolia isnt known to cause any harmful interactions with alcohol. Its recommended that calcium and vitamin D supplements be taken If your dizziness doesnt go away or becomes severe, talk with your doctor. You may wonder how Prolia compares to the medication Zometa. With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. More common side effects in females* who received Prolia for osteoporosis after menopause included: More common side effects in males* who received Prolia for osteoporosis included: More common side effects in people who received Prolia for osteoporosis due to drugs called glucocorticoids included: More common side effects in people who received Prolia to stop bone thinning due to certain cancer treatments included: For a complete list of all the side effects reported with Prolia, see the drugs prescribing information. Prolia side effects: What you should know - Medical Adults over age 50 should not exceed 2,000 mg total per day. Prolia has active ingredients of denosumab. Continue reading, Prolia (denosumab) does increase bone density. The drug could cause your calcium level to drop too low. You will receive your Prolia injection from your healthcare provider at a their office or clinic. Ask your doctor about the pros and cons of using Prolia. Copyright 1996-2023 Cerner Multum, Inc. Bisphosphonates, on the other hand, help increase bone thickness and prevent bone breakdown. What do I need to be aware of if I need a tooth extraction while Im using Prolia? High cholesterol itself doesnt cause any symptoms. In addition, you should use effective birth control while youre taking Prolia. Xgeva is another brand of denosumab used to prevent bone fractures and other skeletal conditions in people with tumors that have spread to the bone. Brush and floss your teeth as directed. Like most drugs, Prolia may cause mild or serious side effects. For example, if you have a serious UTI or other infection, call your doctor right away. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. For Prolia, talk to your pediatrician regarding the use of this medicine in children. Our original studies have been referenced on 600+ medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Some people who take Prolia develop severe bone, joint, or muscle pain. Calcium supplements may help support bone and teeth health. They can explain the risks and benefits of this drug. High cholesterol levels can be a side effect of Prolia. Prolia is also used to treat glucocorticoid-induced osteoporosis in men and women at high risk of bone fracture. Common interactions include nausea among females and fatigue among males. Certain side effects of Prolia that may last longer than others include: Ask your doctor about serious or long-lasting side effects of Prolia and what you should know before starting this drug. Do not stop, skip or delay taking Prolia without first talking with your doctor. These effects are called interactions. Theyll discuss with you other treatments to help protect you from fractures and bone loss. Drug class: miscellaneous bone resorption inhibitors. Additionally, in Prolia-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed. Talk with them about your health and any concerns you have about Prolia and its effects. As you age, your BMD is reduced, and this may increase your risk for osteoporosis. Visit www.fda.gov/medwatch, orcall1-800-FDA-1088. for prostate cancer that has not spread to other parts of the body. Your doctor may also recommend other treatments with Prolia to help increase your bone mass. To learn more about this, see the How is Prolia administered? section below. In rare cases, dental and jaw-related side effects have been reported with Prolia treatment. WebProlia is used to treat osteoporosis in women after menopause and in men, and in people * Sex and gender exist on spectrums. (To learn more, see the Side effect specifics section above.). Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. Use of the term female in this article refers to sex assigned at birth. What should I know about Prolia vs. Tymlos? To prevent osteoporotic fractures, combined calcium and vitamin D supplementation is recommended at the correct dosage (1,0001,200 mg calcium and 800 IU of vitamin D per day). Supplementation should be targeted on vulnerable groups such as elderly and institutionalised people, patients with osteoporosis and individuals on glucocorticoids. Numerous trials have shown that calcium and vitamin D supplementation is effective and safe. In particular, no increased cardiovascular risk was observed. (Chlorhexidine helps kill germs in your mouth.). Common side effects of Prolia can vary depending on which condition the drug is being used to treat. For this reason, some calcium supplements are combined with vitamin D. This vitamin is available in two forms, vitamin D 2 (ergocalciferol) and vitamin It is often used in osteoporosis. Prolia (denosumab) injection, for subcutaneous use. If you have any questions about Prolias side effects, talk with your doctor. Prolia The Prolia is making my leg bones and jaw bones hurt. Weakness and tingling can also occur. Breastfeeding. It comes as a liquid solution thats given as an injection. Prolia For more information about how these medications compare with each other, ask your doctor. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Visit your doctor or health care professional for regular checks on your progress. MEDICATION GUIDE Prolia (PR-lee-a) (denosumab) Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture Various types of osteoporosis medications are available. Prolia is usually given once every 6 months. Below, we answer some common questions about taking Prolia. Prolia comes with a warning about a low level of calcium in the blood. You may want to know how Prolia compares to the medication Tymlos. After you stop taking Prolia, youre more likely to experience bone loss, and your risk of a vertebral fracture increases. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. Cleveland Clinic is a non-profit academic medical center. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. What should I know about Prolia vs. Xgeva? For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. And in my mind, that's no different than scheduling a visit to the dentist twice a year. So, dont be afraid to ask questions or offer feedback on your treatment. Use of the terms female and male in this article refers to sex assigned at birth. These side effects may include: Its not known what percentage of people in clinical trials developed dental or jaw-related side effects. They can help you decide whether the possible benefits for your condition outweigh your risks for serious side effects. These articles might help: Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Your doctor or pharmacist can tell you more about the potential side effects of Prolia and ways to reduce them. This lowers your risk for bone fractures. Over time, Prolia helps to improve the density and strength of your bones by slowing bone loss. This drug may decrease your body's ability to fight infection. This could include having: Before taking Prolia, share your dental history with your doctor. Stopping Prolia doesnt cause withdrawal symptoms. Also describe any vitamins, herbs, or supplements you use. Let your doctor know if you have questions about which drug is recommended for you. Your FRAX score is your risk of having an osteoporosis-related fracture in the next 10 years. Theres no information available to know whether Prolia is passed into breast milk or if its safe to take while breastfeeding. In certain cases, Prolia may have contraindications (not be recommended) for you due to a higher risk for side effects. Talk with your doctor if youd like to know about taking generic denosumab. Please see Prolia full Follow your doctor's instructions. If your Prolia treatment is stopped, talk to your doctor about other medicine that Prolia comes as a solution thats given as an injection under your skin. Lifestyle changes that can help improve cholesterol levels include exercising regularly and eating a healthy diet. But if they become bothersome, talk with your doctor or pharmacist. Youll receive Prolia doses from a healthcare professional. Studies of Prolia didnt report weight gain as a side effect of the drug. DENOSUMAB (den oh sue mab) slows bone breakdown. You may need to have a negative pregnancy test before starting this treatment. There arent any studies that have compared these two drugs to each other. Like Helpful Hug REPLY 1 reply Mamie | @mamie | Oct Your body needs calcium to build and maintain strong bones. Your heart, muscles and nerves also need calcium to function properly. Some studies suggest that calcium, along with vitamin D, may have benefits beyond bone health: perhaps protecting against cancer, diabetes and high blood pressure. Keep in mind that Prolia is used to help strengthen your bones and prevent fractures, which may happen with falls. (Biosimilars are like generic drugs. Prolia is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments Prolia and Calcium drug interactions - eHealthMe See additional information. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. Its a, Forteos active ingredient is teriparatide. Instead, your doctor may recommend that you make certain changes to your diet, such as increasing your calcium and vitamin D intake. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. For more information about how Prolia and Zometa compare with each other, see this article. 2023 Healthline Media LLC. You may be interested in learning how Prolia compares to the medication Fosamax. Theyre commonly used to treat osteoporosis. Different individuals may respond to medication in different ways. If youd like to learn more about Prolia, talk with your doctor or pharmacist. Prolia is an injection prescribed for certain adults with osteoporosis, which Its not known if Prolia is safe or effective for use in children. Prolia contains the active ingredient denosumab. We do not endorse non-Cleveland Clinic products or services. However, drinking too much alcohol may raise your risk of falling. The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. They include: not getting enough calcium and vitamin D smoking drinking too much alcohol using certain medications, such as corticosteroids and anticonvulsants not getting enough weight-bearing exercise (at least 30 minutes on most days). If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. Starting an osteoporosis drug? Here (With off-label use, a drug is used to treat conditions other than those its been approved to treat.). It is given by a health care professional in a hospital or clinic setting. If you have more questions about what to expect with dental procedures while youre taking Prolia, talk with your doctor or dentist. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. A few examples of bisphosphonates include: If youd like to know more about using a bisphosphonate for your condition, talk with your doctor. Allergic reaction. You may have questions about Prolia and your treatment plan. You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia. Your risk may also be higher if you: Stopping Prolia treatment can also increase your risk for bone fractures. Learn more about some of the side effects Prolia may cause. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. If you have a male* sexual partner, they should use birth control during this time as well. Common side effects of this osteoporosis treatment injection include muscle, joint, and back pain. This is because your body doesnt make enough bone, or it loses bone faster than it makes new bone. Your doctor or pharmacist can tell you about any interactions these may cause with Prolia. As mentioned above, Prolia contains the active drug denosumab. * Sex and gender exist on spectrums. The drug may also be used off-label for osteopenia, but usually, you dont need medications for osteopenia. Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. Calcium Some rare side effects of Prolia can be serious and need medical attention. Patients in the study may take other drugs besides Prolia and Calcium. These are not all the possible side effects of Prolia. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and a pre-existing dental problem. (2022). And theyll recommend if its the best option for your condition. Also tell them if you smoke, drink alcohol, or use illegal drugs. For a detailed breakdown of Prolia versus Xgeva, check out this article. Do not share this medicine with another person, even if they have the same symptoms you have. Prolia also carries a warning about hypocalcemia, which is a low level of Biosimilars usually cost less than brand-name drugs. If you are pregnant, you should not take Prolia. (Vitamin D helps your body absorb calcium.) Our phase IV clinical studies alone cannot establish cause-effect relationship. You should not receive Prolia if you are allergic to denosumab, or if you have: low levels of calcium in your blood (hypocalcemia); or. And some of these side effects are more common with certain uses of Prolia. 8,432 people who take Prolia and Calcium together, and have interactions are studied. Problem absorbing minerals. This medicine may cause jaw bone problems (osteonecrosis). What should be considered before taking Prolia? It is important for you to practice good mouth care during treatment with Prolia. For instance, if you have a health condition that causes excess calcium in Prolia is sometimes used in people whose bone fracture is caused by certain medicines or cancer treatments. Can you drink alcohol while taking Prolia? All subjects in the clinical trials of Prolia received 800mg of calcium and The use of the eHealthMe site and its content is at your own risk. I am taking Prolia and just saw that it's important to take Calcium because Prolia takes the calcium out of the blood and that can cause problems. Talk with your doctor about the best options for treating your condition. Any advice? Prolia can also cause bones to not form correctly and reduced growth in a fetus. Try to avoid being around people who are sick. Use of the terms female and male in this article refers to sex assigned at birth. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. Some examples are atorvastatin (Lipitor) and rosuvastatin (Crestor). Symptoms may include jaw pain or numbness, red or swollen gums, loose teeth, gum infection, or slow healing after dental work. Advertising on our site helps support our mission. These side effects may be temporary, lasting a few days or weeks. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. But its believed that these side effects are rare. You should receive your missed injection as soon as possible. Your doctor can also help you decide if the benefits of Prolia treatment outweigh your risks of side effects. They can recommend a treatment option other than Prolia. Before your appointment, write down questions, such as: How will Prolia affect my body, mood, or lifestyle? Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. Although its rare, your doctor may give you the option to self-inject Prolia at home. Now i am worried that i've been taking K2 which also takes calcium from the blood to the bones. Dosage of drugs is not considered in the study. It does the same thing that. If you develop serious side effects while taking Prolia, call your doctor right away. The phase IV clinical study analyzes what interactions people who take Prolia and Calcium have. Theyll discuss with you other treatments to help prevent bone loss. Courtney Sullivan, Certified Yoga Instructor, Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT. Some side effects of Prolia may go away on their own within a few days or weeks after starting treatment. It may also be higher if you have dental work done while youre taking Prolia. Pay special attention to your dental hygiene. You are encouraged to report negative side effects of prescription drugs to the FDA. It can have some side effects, but these may depend on who uses it. Our website services, content, and products are for informational purposes only. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. Prolia injections administered by a healthcare professional. eHealthMe is studying from 146,783 Calcium users for its effectiveness, alternative drugs and more. You may also want to do some research on your own. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medicine only for the indication prescribed. What is the most important information I should know about Prolia? Factors to consider include those in the list below. They may help you identify other possible causes or suggest ways to help manage hair loss. Its important to tell your doctor if you have serious or ongoing side effects. Usually, but it depends. Get the treatment that fits your lifestyle, Stay informed with courtesy reminders, recipes and so much more. But this isnt the case with Prolia. Prolia may be used off-label for RA, if you have a high risk for bone fractures. This is called hypocalcemia. But its not clear how often this side effect occurred in clinical trials. If you have serious side effects from Prolia, call your doctor right away. Its also recommended that you use birth control while taking Prolia and for 5 months or more after your last dose. Bone pain from Prolia may be most noticeable in your arms and legs. Yes, if recommended by your doctor, you can stop taking Prolia. Prolia (denosumab) and Reclast (zoledronic acid) are injections that can be used to treat or prevent osteoporosis in postmenopausal women. For more information about the uses of Prolia, see the Is Prolia used for osteoporosis? and Is Prolia used for other conditions? sections below.
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